SNPs and NPs 1 THE RELATIONSHIP OF SINGLE NUCLEOTIDE POLYMORPHISMS AND INFLAMMATORY MARKERS OF CORONARY ARTERY DISEASE: SIGNIFICANCE FOR NURSE PRACTITIONERS IN AN ACUTE CARE SETTING by
نویسندگان
چکیده
The purpose of this paper is to elucidate the need for acute care nurse practitioners (ACNPs) to understand the significance of single-nucleotide polymorphisms (SNPs) and how they correlate with blood levels of certain inflammatory markers; an increase in blood levels of these markers may lead to coronary artery disease (CAD) and its sequelae. Genetic research regarding CAD is comparatively sparse. A comprehensive review of research articles describing the effects of three primary inflammatory markers and associated genetic polymorphisms on CAD and coronary sequelae was performed; findings revealed several key SNPs that have been shown to both increase inflammatory marker levels and increase clinical coronary-related events. ACNPs need to keep their practice up-to-date by synthesizing genetics research studying both inflammatory markers and SNPs. Appropriate management strategies include awareness of inflammatory marker levels and early pharmacological intervention.
منابع مشابه
Association of two Common Single Nucleotide Polymorphisms (SNPs +45T/G and +276G/T) of ADIPOQ Gene with Coronary Artery Disease in Type 2 Diabetic Patients
Background: Adiponectin, an adipocyte-secreted hormone, is known to have anti-atherogenic, anti-inflammatory, and anti-diabetic properties. In the present study, the association between two common single nucleotide polymorphisms (SNPs) (+45T/G and +276G/T) of ADIOPQ gene and coronary artery disease (CAD) was assessed in the subjects with type 2 diabetes (T2DM). Methods: Genotypes of two SNPs we...
متن کاملSingle Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease
Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorp...
متن کاملICAM-1 Polymorphisms (G241R, K469E), in Coronary Artery Disease and Myocardial Infarction
Background: Inflammation plays a critical role in atherogenesis. The initial step in atherosclerosis is the adhesion of leukocytes to activated endothelial cells mediated by ICAM-1, an inflammatory protein. Several polymorphisms for Intracellular adhesion molecule -1(ICAM-) gene have been described. Objective: To determine the possible role of G241R and K469E polymorphisms in development of cor...
متن کاملEvaluation of Relationship between Single-nucleotide Polymorphism in TNF-gene Promoter and Susceptibility to Atherosclerosis in Fatemeh Zahra Hospital
Background: Tumor necrosis factor alpha is a proinflammatory cytokine and as polyvalent initial response of inflammatory cells which facilitated through the creation of coronary atherosclerosis . It also seems that the polymorphism and susceptibility to atherosclerosis is related to TNF-α gene promoter. The purpose of this study was to investigate single nucleotide polymorphis...
متن کاملAssociation between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers
This study determined the genotype effects of interleukin (IL)-6/IL-6R single nucleotide polymorphisms (SNPs) on circulating levels of different cytokines in healthy and coronary artery disease (CAD) patients with different allele frequencies. In the control patients, rs1800795 showed significant differences in IL-18 concentrations between CC and CG and CC and GG genotypes (P=0.003 and 0.004, r...
متن کامل